Depression induced by etretinate.

Drug Points Depression induced by etretinate

Drs C A HENDERSON and A S HIGHET (York District Hospital, York Y03 7HE) write: We report three cases of depression associated with etretinate treatment. In 1984 a 49 year old, 90 kg man with plaque psoriasis started taking etretinate 100 mg/day. Despite a reduction in dose the drug had to be discontinued owing to peeling skin, thinning hair, and depression. These effects resolved a few weeks la...

Hair discoloration caused by etretinate.

Etretinate improves localized porokeratosis of Mibelli.

A 60-year-old woman with plaque-type psoriasis of 30 years' duration was treated with etretinate. The lesion resolved while the patient was on the drug and continued to resolve after she had discontinued therapy. The continuation of resolution after the patient had discontinued the drug is probably due to its long half-life.

Effects of etretinate on epidermal Langerhans cell.

The effect of etretinate, applied systemically, on epidermal Langerhans cells was studied. The numbers and shapes of Langerhans cells were observed on split epidermis, and the percentage of Langerhans cells in whole epidermal cells was determined with a flow cytometrial system. On an epidermal sheet, the number of Langerhans cells changed biphasically, first the number increased, then decreased...

The effects of swimming exercise and Nepeta menthoides on depression and anxiety induced by reserpine

Background and Objective: Physical activity has long been associated with mental health. Nepeta menthoides is a native Iranian herb recently acknowledged for its anti-depressant properties. This study attempted to determine and compare the effects of swimming exercise and Nepeta menthoides on reserpine-induced depression in rats.Materials and Methods: Male rats (n=80) were assigned to 8 g...